Periodic Fever Syndrome Market at $881.95 Mn in 2032,4.1% CAGR

Periodic Fever Syndrome Market Market Size Worth $881.95 Million By 2032 | CAGR: 4.1%

The global periodic fever syndrome market size is expected to reach USD 881.95 million by 2032, according to a new study by Polaris Market Research. The report “Periodic fever syndrome Market Share, Size, Trends, Industry Analysis Report, By Indication (Hyper-immunoglobulinemia D syndrome, Familial Mediterranean Fever, TNF Receptor Associated periodic syndrome, Cryopyrin Associated periodic syndrome, Others); By Treatment; By End-Use; By Region; Segment Forecast, 2024 - 2032” gives a detailed insight into current market dynamics and provides analysis on future market growth.

The rise of the sector is being aided by a rise in government programs focused on raising public knowledge of uncommon disorders. Increased research activity and quick technical breakthroughs are resulting in the creation of new medications, enhanced diagnostic capabilities, and treatments, all of which contribute significantly to market growth. The sector is likely to benefit from new medication approvals to treat the condition.

FMF is the most prevalent monogenic autoinflammatory illness in the world and in Canada, with repeated, self-limited bouts of fever and inflammation involving serous and synovial membranes. It is inherited in an autosomal recessive manner, and its incidence is highest among groups of Middle Eastern and Mediterranean ancestry, with varying prevalence in other ethnicities.

Cryopyrin-associated periodic syndrome (CAPS) is a series of autoinflammatory illnesses that are connected. Mutations in the CIASl gene, which encodes cryopyrin, induce the enhanced activity of interleukin I and other cytokines, which activate their target cells via an intracellular receptor known as the Toll-like receptor or nucleotide oligomerization domain protein ligation.

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Ilaris is the first and only FDA-approved biologic therapy for TRAPS, Hyper immunoglobulin D Syndrome, & Familial Mediterranean Fever. All three disorders are part of a rare category of auto-inflammatory diseases known as Periodic Fever Syndromes. FMF is the most frequent condition, affecting primarily those of Eastern Mediterranean heritage. It affects 1 in 250 to 1 in 1,000 people in various populations, with a majority of them being children.

Commonly used medications, such as hydroxychloroquine, have seen a huge increase in demand for COVID-19 control. Because of the need for vaccinations and treatment medications for COVID-19, the biopharma industry is likely to increase significantly in the future. This, in turn, is projected to have a major influence on the market for periodic fever syndrome. Recently, Canakinumab has been licensed for the treatment of individuals with periodic fever syndrome, cryopyrin-associated periodic syndrome, periodic fever syndrome, and systemic juvenile systemic arthritis which likely boosts the growth of periodic fever syndrome business.

Periodic Fever Syndrome Market Report Highlights

  • Oral anti-inflammatory medicines such as corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs), among others, are expected to hold a significant market share over the projection period as these are used to treat periodic fever syndrome.
  • North America is a market leader in the worldwide periodic fever syndrome sector due to the expanding penetration of the region's key companies and the increased emphasis on patient care and monitoring.
  • The global players include Merck & Co Inc, Simvastatin, Swedish Orphan Biovitrum AB, and Novartis AG.

Polaris Market Research has segmented the periodic fever syndrome market report based on indication, treatment, end-use and region:

Periodic Fever Syndrome, Indication Outlook (Revenue - USD Million, 2019 - 2032)

  • Hyperimmunoglobulinemia D syndrome
  • Familial Mediterranean Fever (FMF)
  • TNF Receptor Associated Periodic Syndrome (TRAPS)
  • Cryopyrin Associated Periodic Syndrome
  • Others

Periodic Fever Syndrome, Treatment Outlook (Revenue - USD Million, 2019 - 2032)

  • Oral anti-inflammatory drugs
  • Non-steroidal anti-inflammatory drugs (NSAIDs)
  • Anti-TNF therapy
  • Statins
  • Others

Periodic fever syndrome, End-Use Outlook (Revenue - USD Million, 2019 - 2032)

  • Hospitals
  • Retail Pharmacy

Periodic fever syndrome, Regional Outlook (Revenue - USD Million, 2019 - 2032)

  • North America
  • U.S.
  • Canada
  • Europe
  • Germany
  • UK
  • France
  • Italy
  • Spain
  • Russia
  • Netherlands
  • Asia Pacific
  • China
  • India
  • Japan
  • South Korea
  • Indonesia
  • Malaysia
  • Latin America
  • Argentina
  • Brazil
  • Mexico
  • Middle East & Africa
  • UAE
  • Saudi Arabia
  • Israel
  • South Africa

Periodic Fever Syndrome Market Report Scope

Report Attributes


Market size value in 2024

USD 637.29 million

Revenue forecast in 2032

USD 881.95 million


4.1% from 2024 - 2032

Base year


Historical data

2019 - 2022

Forecast period

2024 – 2032

Quantitative units

Revenue in USD million and CAGR from 2024 to 2032

Segments Covered

By Indication, By Treatment, By End-Use, By Region

Regional scope

North America, Europe, Asia Pacific, Latin America; Middle East & Africa


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