L-ergothioneine Market Size, Share, Global Analysis Report, 2024-2032
L-ergothioneine Market Size, Share, Global Analysis Report, 2024-2032

L-ergothioneine Market Share, Size, Trends, Industry Analysis Report, By Type (Biosynthesis, Chemical Synthesis, Biological Fermentation); By Application; By Region; Segment Forecast, 2024 - 2032

  • Published Date:Jan-2024
  • Pages: 115
  • Format: PDF
  • Report ID: PM4173
  • Base Year: 2023
  • Historical Data: 2019 – 2022

Report Outlook

The global l-ergothioneine market was valued at USD 39.59 million in 2023 and is expected to grow at a CAGR of 36.4% during the forecast period.

L-ergothioneine, a sulphur-containing amino acid, is certainly identified in foods, mainly in fungi. This compound is highly utilised in cosmetics, dietary supplements, and other applications due to its anti-inflammatory and anti-oxidant properties. The ongoing consumer preferences towards healthy skin and rising investments in beauty products are driving the demand for l-ergothioneine by skincare product manufacturers due to its potential ability to fade signs of discoloration, reduce wrinkles, make people's skin look younger, and provide soothing benefits.

L-ergothioneine Market Size

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Furthermore, based on the study published in the Redox Biology journal in 2023, a project conducted by the IDIBELL Human Molecular Genetics group showcased that the utilisation of the L-Ergothioneine, an antioxidant in the Cystinuria diseased mouse model postponed their onset due to its chronic & preventive administration. This is demonstrating the ability of l-ergothioneine to deter the formation of cystine stones; however, further clinical trials are needed for the creation of a new treatment for cystinuria. Researchers are increasing their focus to delve into the properties of this natural antioxidant.

  • For instance, in November 2022, a study published in Science Direct in the Experimental Gerontology journal focused on reviewing the properties of ergothioneine. It found that it has anti-senescence, anti-neurodegenerative, and anti-inflammatory properties. It also evaluated the major ageing pathways, including insulin growth factor, sirtuin 6, and the mammalian target of the rapamycin complex.

Moreover, ergothioneine is considered a rich diet with the capability to promote healthy ageing and control age-related health problems in the population.

However, the higher production costs, limited knowledge among the people, supply chain disruptions, and lesser scientific studies on l-ergothioneine are restraining the growth of the market.


Growth Drivers

  • The increasing studies to enhance the production of l-ergothioneine

The rising research studies in finding a feasible production process, along with the applications of ergothioneine, are positively impacting the growth of the market. A study published in BMC, the microbial cell factories journal, focused on finding a more efficient ergothioneine production process by a fungal biosynthetic pathway. It evaluated the genetic engineering technique to produce a more cost-effective plan. The study results found that E. coli witnessed ergothioneine overproduction, offering an optimal approach to commercial production of ergothioneine. This method of production is likely to be adopted by the companies, contributing to the increased supply of ergothioneine in the global space and leading to stabilized market pricing.

In addition, l-ergothioneine showed a positive outlook for protecting dextran sulphate sodium-induced colitis in mice, according to the 2022 study published in ACS publications. The study results found that higher consumption of l-ergothioneine led to a reduction in body weight and colon shortening. As more studies evaluate the effectiveness of antioxidant properties in treating various human health issues, this is likely to propel its demand in the pharmaceutical industry

Furthermore, there are studies going on to evaluate the use of l-ergothioneine in the therapeutic treatment of Alzheimer's disease. This is driven by its ability to reduce oxidative stress and penetrate the brain. This study is in favor of creating new opportunities for global market expansion.

Report Segmentation

The market is primarily segmented based on type, application, and region.

By Type

By Application

By Region

  • Biosynthesis
  • Chemical Synthesis
  • Biological Fermentation


  • Medical
  • Cosmetics
  • Food Industry
  • Others



  • North America (U.S., Canada)
  • Europe (France, Germany, UK, Italy, Netherlands, Spain, Russia)
  • Asia Pacific (Japan, China, India, Malaysia, Indonesia. South Korea)
  • Latin America (Brazil, Mexico, Argentina)
  • Middle East & Africa (Saudi Arabia, UAE, Israel, South Africa)

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By Type Analysis

  • Biological Fermentation segment is expected to witness the highest growth during the forecast period

The biological fermentation segment will grow at the rapid pace, mainly driven by its increased and sustainable production. The rising demand for l-ergothioneine in skin care product formulations, health supplements, and natural health compounds is fueling the need for biological fermentation processes by manufacturers. Furthermore, most of the producers are showing interest in opting for biological fermentation processes in ergothioneine production, attributable to their cost-effectiveness in the long run.

The chemical synthesis segment held the substantial revenue share, largely attributable to its ability to offer high-quality l-ergothioneine production by conducting specific chemical reactions. This is gaining importance due to the lower supply in the market. It is versatile in nature as it can be customized for usage in different applications, including pharmaceuticals, skincare, and more, driving the adoption of chemical synthesis in the production of l-ergothioneine by manufacturers.

By Application Analysis

  • Medical segment registered the largest market share in 2023

The medical segment accounted for the largest revenue share. The increased availability of research studies showing significant benefits associated with ergothioneine is driving its utilisation in the pharmaceutical space. The growing significance of research in treating chronic diseases and neurological disorders is encouraging researchers to continue further research activities. This factor is expected to stimulate the expansion of the global market.

The cosmetics segment is expected to grow at the fastest rate over the next few years on account of the rising adoption of cosmetic product formulations. The application of l-ergothioneine in the cosmetics segment is grabbing popularity, driven by its ability to repair cells from oxidative stress and environmental damage. 

L-ergothioneine Market Size

Regional Insights

  • Europe region registered the largest share of the global market in 2023

The Europe region held the global market with the largest share. This is attributable to the higher consumption of l-ergothioneine in this region due to the European Food Safety Authority's approval of this compound as a dietary supplement among infants, children, breastfeeding women, and pregnant women.

According to a 2020 study published in the Cambridge journal estimation, Italy is the highest consumer of l-ergothioneine per day compared to the U.S., Finland, France, and Ireland and has lower mortality, mortality with neurological disorders, per 100,000. Italy has also registered a higher life expectancy. The study revealed that higher consumption of l-ergothioneine is associated with increased life expectancy, lower mortality, and lower mortality from neurological disorders, and vice versa. The continual government initiatives to promote clean-labelled products are likely to promote the demand for l-ergothioneine in this region.

The North America region will grow rapidly, owing to the growing consumption of dietary supplements in the region. With the daily diet, it is getting difficult for people to get the required vitamins, minerals, and essential compounds for body functioning. This is encouraging working professionals to opt for dietary supplements, as they usually have less time for food consumption. The ongoing demand for natural antioxidants is also boosting the need for l-ergothioneine in dietary supplements.

L-ergothioneine Market Size

Key Market Players & Competitive Insights

The l-ergothioneine market is fragmented with the presence of several market players and is expected to witness competition attributable to the rising applications in numerous fields. The increasing product innovations in the cosmetics, food, and pharmaceutical industries are gaining attention for ergothioneine compounds, driving their demand in the future. For instance, in August 2022, Aperion Zon introduced AEON, a longevity product, to reduce ageing in its consumers. Ingredients include L-ergothioneine, di-hydroberberine, spermidine, and more. 

Some of the major players operating in the global market include:

  • Blue California
  • BOC Sciences
  • Jiangyin Healthway International Trade Co., Ltd
  • Mironova Labs, Inc.
  • Oxis International
  • Santa Cruz Biotechnology, Inc.
  • Sigma-Aldrich
  • Tetrahedron
  • Total Nutraceutical Solutions, Inc.

Recent Developments

  • In June 2022, a study published in Mary Ann Liebert website, which was supported by the American Heart Association, focused on investigating the neuroprotective and cytoprotective properties of l-ergothioneine. It is found that it can cross the blood-brain barrier, has anti-ageing, vascular, and neuroprotective properties, and is found as a non-toxic compound that is even found in foods.

L-ergothioneine Market Report Scope

Report Attributes


Market size value in 2024

USD 53.75 million

Revenue forecast in 2032

USD 644.90 million


36.4% from 2024 – 2032

Base year


Historical data

2019 – 2022

Forecast period

2024 – 2032

Quantitative units

Revenue in USD million and CAGR from 2024 to 2032

Segments covered

By Type, By Application, By Region

Regional scope

North America, Europe, Asia Pacific, Latin America, Middle East & Africa


Report customization as per your requirements with respect to countries, region and segmentation.


The l-ergothioneine market report covering key segments are type, application, and region.

L-ergothioneine Market Size Worth $644.90 Million By 2032

The global l-ergothioneine market is expected to grow at a CAGR of 36.4% during the forecast period.

Europe is leading the global market

key driving factors in l-ergothioneine market are Growing Cosmetic and Personal Care Industry