Enzymatic DNA Synthesis Market Size Worth USD 3,063.36 Million by 2034 | CAGR: 26.85%

The enzymatic DNA synthesis market size is expected to reach USD 3,063.36 Million by 2034, according to a new study by Polaris Market Research. The report “Enzymatic DNA Synthesis Market Size, Share, Trends, Industry Analysis Report By Services (Oligonucleotide Synthesis and Gene Synthesis), By Technology, By Application, By End Use, and By Region – Market Forecast, 2025–2034” gives a detailed insight into current market dynamics and provides analysis on future market growth.

Enzymatic DNA synthesis technologies are increasingly adopted across biotechnology, pharmaceutical, and academic research applications, as it provide faster, cleaner, and more accurate production of oligonucleotides while addressing the efficiency, error rate, and environmental limitations associated with conventional chemical synthesis methods.

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The market is expanding significantly due to the rising demand for precision medicine and synthetic biology solutions, the growing application of enzymatic synthesis in genomics, diagnostics, and pharmaceutical research, and the accelerating need for scalable, cost-effective, and environmentally sustainable DNA manufacturing methods. Rising innovations in enzymatic processes, coupled with supportive investments from governments and private organizations, are further enhancing the adoption of these technologies.

Enzymatic DNA Synthesis Market Report Highlights

• Based on services, the oligonucleotide synthesis segment dominated the market in 2024, due to its extensive use in molecular diagnostics, PCR assays, next-generation sequencing, and targeted drug discovery programs that require high-quality synthetic DNA.
• In terms of technology, PCR accounted for the largest share in 2024, owing to its established role in research and clinical diagnostics, enabling high-throughput DNA amplification for genetic analysis, infectious disease detection, and oncology applications.
• In terms of application, synthetic biology is dominating the market in 2024, driven by its widespread adoption in designing genetic circuits, metabolic engineering, and developing bio-based materials, fuels, and advanced therapeutics.
• Based on end use, the biopharmaceutical companies segment led the market in 2024, supported by the growing focus on developing gene-based therapies, precision medicine, and biologics that depend on efficient, accurate, and scalable DNA synthesis solutions.
• North America captured a dominant share in 2024, attributed to the strong presence of leading biotechnology and pharmaceutical companies, robust research infrastructure, and high R&D investments across genomics and life sciences.
• Asia Pacific is projected to record the fastest growth during the forecast period, fueled by rising government funding, national initiatives focused on synthetic biology, and expanding life sciences research hubs across countries such as China, India, and Singapore.
• Key players in the global market include Aldevron LLC (Danaher Corporation), Almac Group Limited, Ansa Biotechnologies, Inc., Biotium, Inc., Camena Bioscience Ltd., DNA Script SAS, Elegen Corporation, Evonetix Ltd., GenScript Biotech Corporation, Kern Systems, Inc., Merck KGaA, Molecular Assemblies, Inc., Telesis Bio Inc., Touchlight Genetics Ltd., and Twist Bioscience Corporation.

Polaris Market Research has segmented the market report based on services, technology, application, end use, and region:

By Services Outlook (Revenue, USD Million, 2020–2034)

• Oligonucleotide Synthesis
• Gene Synthesis

By Technology Outlook (Revenue, USD Million, 2020–2034)

• SOLA
• CRISPR
• PCR

By Application Outlook (Revenue, USD Million, 2020–2034)

• Synthetic Biology
• Genetic Engineering
• Vaccine Development
• Others

By End Use Outlook (Revenue, USD Million, 2020–2034)

• Biopharmaceutical Companies
• Academic & Research Institutes
• Contract Research Organizations

By Regional Outlook (Revenue, USD Million, 2020–2034)

• North America
  • US
  • Canada
• Europe
  • Germany
  • France
  • UK
  • Italy
  • Spain
  • Netherlands
  • Russia
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • Malaysia
  • South Korea
  • Indonesia
  • Australia
  • Vietnam
  • Rest of Asia Pacific
• Middle East & Africa
  • Saudi Arabia
  • UAE
  • Israel
  • South Africa
  • Rest of Middle East & Africa
• Latin America
  • Mexico
  • Brazil
  • Argentina
  • Rest of Latin America