The global cell culture market is estimated to be USD 18.98 billion in 2020 and is expected to grow at a CAGR of 11.6% during the forecast period. Since biotechnology has gained central importance for the R&D of newer healthcare and biological applications, living cells and tissues have become central to any and all research activity.
Therefore, this market and its applications in the field of molecular biological R&D have remained and are expected to remain a critical factor for any further development. With the advent of genetic engineering, recombinant DNA technology, genomic and proteomic profiling, the techniques have become indispensable.
Usage of the technique has increased to an extent where traditional small-scale production and handling of cultures falling short of the increasing demand. This has encouraged the development of automated large-scale systems which are capable of producing high throughput with excellent purity and in larger quantities. The continued development of the techniques and applications has poised this market to expect a steady and substantial growth through to 2028.
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Product segments in this market include culture systems, incubators, pipetting instruments, biosafety, and cryo-storage equipment. Further classification of culture systems includes plates, bags, T-flasks, roller bottles, bioreactors, and centrifuges.
Culture systems are expected to have the largest market share as they are an integral part of the process. Moreover, with advancement in the development of spheroid and complex bioreactors and with the introduction of 3D cell culture, this segment has gained significant momentum.
These factors along with the culture systems which include robotic automated liquid handling instruments and sophisticated separator systems are more expensive as opposed to the other segments, it is expected that the system segment will continue to dominate this market. With the seemingly estimated introduction of extremely automated robotic laboratory equipment, this segment is also poised to grow at a considerable CAGR through to 2028.
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The technique finds applications in the fields of biotech research and molecular studies, cancer study, gene therapy, toxicity testing, tissue engineering, drug development, manufacturing of biopharmaceuticals, and production of vaccines. A thorough study of the market reveals that the highest revenue generated in the market through the application of the culture is in the fields of manufacturing biopharmaceuticals followed by the production of vaccines.
A very important factor contributing to this dominance is the fact that a mass culture of animal cells, especially mammalian, is an elementary step for the fabrication of biotechnological products, primarily viral vaccines. Owing to the innovations in genetic engineering there has been a significant increase in the usage of protein-based biopharmaceuticals. Their production is greatly dependent on the protein expression systems derived from mammalian cultures and the construction of high-yielding cell lines.
This recently developed application of the process in the biopharmaceutical segment is responsible for most of the revenue generated from this segment and is also expected to be the primary cause for the same throughout the forecast period.
The consumable market section consists of cell culture media, sera as well as reagent markets. The greatest development amongst these sections is being observed in the media market. The market is driven by enhancing upright assimilation, development of the biopharmaceutical market owing to boosting the need for different media choices.
Cell culture media creates the biggest share (by volume) for any kind of preparation. As contrasted to typical market rates of sera as well as reagents, media loosely price but has high consumption value. Expanding need for culturing in cytological projects, it is anticipated that the section will certainly witness significant growth over the projected period.
The largest share of revenue generated globally was accounted for by North America in 2020. Owing to the introduction and progress of automated techniques and increasing usage of stem cell therapy in the region.
The technique finds the most application in the U.S. and Canadian life science laboratories. In the U.S. alone, the automation for cell-based assays such as induced pluripotent stem cell research, cellular expression, culturing of monoclonal antibodies (MaBs) and cryobanking accounted for about a third of the revenue generated.
Development of automatic single cell examination and segregation systems in Asia Pacific region, especially Japan, for advanced research in stem cell therapies is also expected to fuel the market during the foreseeable future and account for the expected growth of the Asia Pacific region in the coming years.
Key participants of the market include Thermo Fisher Scientific, Sartorius, Merck, Sigma-Aldrich Co., LLC, Promocell, Lonza, Eppendorf, and Becton, Dickinson & Company. Due to the advanced developments in bioreactors, the companies are also involved in the introduction and improvement of 3D culture techniques which are a step up from the conventional 2D techniques. Three-dimensional cell colonies which are obtained from 3D cultures are more accurate models of in vivo cells and it is expected that their development will further fuel market growth.