U.S. Next-Generation Sequencing Library Preparation Market Size Worth USD 2,167.71 Million by 2034 | CAGR: 12.83%

The U.S. next-generation sequencing library preparation market size is expected to reach USD 2,167.71 million by 2034, according to a new study by Polaris Market Research. The report “U.S. Next-Generation Sequencing Library Preparation Market Share, Size, Trends, Industry Analysis Report By Sequencing Type (Targeted Genome Sequencing, Whole Genome Sequencing), By Product, By Application, By End Use; Market Forecast, 2025–2034” gives a detailed insight into current market dynamics and provides analysis on future market growth.

Next-generation sequencing library preparation is a crucial step in the sequencing workflow, involving the conversion of DNA or RNA samples into a format compatible with high-throughput sequencing platforms. The process includes fragmenting the nucleic acids, attaching specialized adapter sequences, and amplifying the material to generate a sequencing-ready library. The quality of library preparation directly impacts the accuracy and efficiency of sequencing.

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Next-generation sequencing library preparation is widely used across genomics research, clinical diagnostics, and biotechnology. In whole-genome sequencing (WGS), it enables comprehensive analysis of an organism’s DNA, aiding in genetic variant detection and evolutionary studies.

Top of FormU.S. Next-Generation Sequencing Library Preparation Market Report Highlights

• In terms of sequencing type, the targeted genome sequencing segment accounted for 63.37% of revenue market share in 2024. Clinical researchers and diagnostic laboratories favored this approach due to its cost-effectiveness, high accuracy, and efficiency in identifying specific genetic variants associated with inherited diseases and cancers.
• The whole genome sequencing segment, based on sequencing type, is projected to hold a substantial share in the coming years, owing to advancements in sequencing technologies and declining costs.
• Based on product, the reagents & consumables segment dominated the market share in 2024 due to recurring demand for library preparation kits, enzymes, adapters, and amplification reagents used in every sequencing run.
• In terms of application, the drug & biomarker discovery segment held the largest revenue share in 2024 due to the crucial role of next-generation sequencing library preparation in precision medicine and pharmaceutical research.
• Based on end use, the academic and research institutions segment accounted for 37.83% of revenue market share in 2024 due to strong federal and private funding for genomics research and large-scale sequencing projects.
• A few key players in the U.S. next-generation sequencing library preparation market include Agilent Technologies, Inc.; BD; F. Hoffmann-La Roche AG, Inc.; Illumina, Inc.; New England Biolabs Inc.; Oxford Nanopore Technologies; Pacific Biosciences of California, Inc.; QIAGEN N.V.; Revvity, Inc.; Thermo Fisher Scientific Inc.; and Twist Bioscience.

Polaris Market Research has segmented the U.S. next-generation sequencing library preparation market report on the basis of sequencing type, product, application, and end use:

By Sequencing Type Outlook (Revenue, USD Million, 2020–2034)

• Targeted Genome Sequencing
• Whole Genome Sequencing
• Whole Exome Sequencing
• Other

By Product Outlook (Revenue, USD Million, 2020–2034)

• Reagents & Consumables
  • DNA Library Preparation Kits
  • RNA Library Preparation Kits
  • Other
• Instruments

By Application Outlook (Revenue, USD Million, 2020–2034)

• Drug & Biomarker Discovery
• Disease Diagnostics
  • Cancer Diagnostics
  • Reproductive Health Diagnostics
  • Infectious Disease Diagnostics
  • Other
• Others

By End Use Outlook (Revenue, USD Million, 2020–2034)

• Hospitals and Clinics
• Academic and Research Institutions
• Pharmaceutical and Biotechnology Companies
• Others